Medical publications

Combining Genome Change Index (GCI) and liquid biopsy to predict and monitor therapeutic responses.

Ekkehard Schütz, Julia Beck, Donald Peter Braun, Howard B. Urnovitz , et al. Combining Genome Change Index (GCI) and liquid biopsy to predict and monitor therapeutic responses.J Clin Oncol 33, 2015 (suppl; abstr e22020) .

Genomic instability of tumor cells has been associated with a poor prognosis. However, impaired DNA repair pathways leading to genomic instability are also described to increase tumor sensitivity to DNA damaging agents. A comprehensive Genomic Change Index (GCI) as an indicator of defective DNA repair is proposed as a potential predictor of cytotoxic chemotherapy (chemo) response.

Quantifying copy number variations in cell-free DNA for potential clinical utility from a large prostate cancer cohort.

Ekkehard Schütz, Howard B. Urnovitz, et al. Quantifying copy number variations in cell-free DNA for potential clinical utility from a large prostate cancer cohort J Clin Oncol 31, 2013 (suppl; abstr 5072).

Prostate cancer (PrCa) is the most frequent non-dermatological malignancy in the male population. Genomic instability resulting in copy number variation (CNV) is a hallmark of malignant transformation.

Cell Free DNA accurately correlates with breast cancer DNA

Howard B. Urnovitz, Modulation of breast cancer cell-free DNA with surgical resection. J Clin Oncol 31, 2013 (suppl; abstr 11060)

Researchers from Chronix Biomedical and The University of Texas MD Anderson Cancer Center announced results from a pilot study demonstrating the utility of cell-free DNA (cfDNA) blood tests as a companion diagnostic for breast cancer patients at the American Society of Clinical Oncology Annual Meeting (ASCO 2013).

Clinica Highlights Chronix Biomedical’s Diagnostics

Tina Tan, Chronix’s new liquid biopsy approach show promise as early predictor of cancer therapies. Clinica, 18 April 2016.

A blood-based test which looks at chromosomal gains and losses in cell-free DNA (cfDNA) has demonstrated its potential of being a predictor of how well cancer patients are responding to chemotherapy.

Chronix Biomedical to present clinical data on its cell-free DNA approach as an early predictor of response to chemotherapy at the AACR Annual Meeting

Howard B. Urnovitz, Ekkehard Schutz, et al. Changes in tumor cell-free DNA copy number instability (CNI) predict therapeutic response in metastatic cancers AACR, 19 April 2016

Tumor cell-free DNA (cfDNA) has the potential to provide minimally invasive patient specific biomarkers to monitor tumor burden. Gains and losses of chromosomal regions - as a hallmark of cancer - have been detected in plasma as copy number aberrations (CNAs), and for several cancers a relation to tumor size has been reported.